{"id":13790,"date":"2026-06-01T16:00:00","date_gmt":"2026-06-01T14:00:00","guid":{"rendered":"http:\/\/stocks-future.com\/?guid=4dfa066a98f890dbe0f19cce0e7aa792"},"modified":"2026-06-01T16:00:00","modified_gmt":"2026-06-01T14:00:00","slug":"bruker-announces-major-strides-in-4d-proteomics-performance-further-advances-in-intact-and-top-down-functional-proteoform-analysis-and-innovations-in-hybrid-qual-quant-4d-metabolomics-all","status":"publish","type":"post","link":"https:\/\/stocks-future.com\/?p=13790","title":{"rendered":"Bruker Announces Major Strides in 4D Proteomics Performance, Further Advances In Intact and Top-Down Functional Proteoform Analysis, and Innovations in Hybrid Qual\/Quant 4D Metabolomics \u2013 all to Enable Deeper Insights into Disease Biology"},"content":{"rendered":"

\nBruker Also Launches Two Novel Mass Spectrometry Systems for Unique Applications in Energy Industry Research, and in Semiconductor Manufacturing<\/b><\/p>

    \n
  1. \nLaunch of eXtreme 10M resolution novel timsMRMS<\/i>\u2122 mass spectrometer for ultra-complex mixture analysis in energy industry and life-science research<\/b><\/li>\n
  2. \nBreakthrough timsUltra\u2122 AIP<\/i> bottom-up proteomics performance: instrument improvements, new razor-PASEF\u2122 methods and Spectronaut 21 software enable ID and LFQ beyond 10,000 proteins in cell lines and tissue, with >6,500 proteins at 500 SPD, and leading plasma proteomics performance with single-particle P2 enrichment<\/b><\/li>\n
  3. \nRevolutionary timsOmni\u2122<\/i> enables unmatched multi-stage, ultra-sensitive trapped ExD (tExD) fragmentation for deeper structural and functional characterization of proteoforms and PTMs, with even greater top-down 4x sensitivity, including for glycoproteomics and small molecule structural characterization<\/b><\/li>\n
  4. \nNew partnership with Integrated Protein Technologies<\/i> for high-throughput sample preparation for intact and top-down biotherapeutic characterization on timsOmni<\/i><\/b><\/li>\n
  5. \nLaunch of KOL early-access program to \u2018holy grail\u2019 hybrid workflow combining targeted metabolomics with absolute quantitation using Biocrates kits, and simultaneous untargeted 4D metabolomics discovery<\/b><\/li>\n
  6. \nLaunch of novel TOFWERK airborne molecular contaminants (AMC) TOF-MS solutions for yield optimization in semiconductor manufacturing; multi-million-dollar multiple-systems order received from leading global memory manufacturer<\/b><\/li>\n<\/ol>

    SAN DIEGO--(BUSINESS WIRE)--$BRKR<\/a> #BRKR<\/a>--At ASMS, Bruker Corporation<\/a> (Nasdaq: BRKR) announced the launch of the unique timsMRMS system, bringing the power of trapped ion mobility separation to ultra-high-resolution magnetic resonance mass spectrometry (MRMS).<\/p>

    \nA translational oncology research initiative by Prof. Stephan Singer at University Hospital T\u00fcbingen enables therapy selection, measuring more than 10,000 proteins in FFPE biopsies to reveal actionable tumor biology when precision genomics is inconclusive.<\/p><\/a><\/a><\/a><\/a>

    \nMajor timsUltra AIP<\/i> and further timsOmni<\/i> advances, razor-PASEF workflows, Spectronaut 21 and OmniScape software advance proteomics to >10,000 proteins per sample, more than 6,500 proteins at 500 samples per day (SPD), and make sensitive and information-rich top-down characterization 4x more sensitive for proteoforms, antibodies, glycoproteins, oligonucleotides.<\/p>

    \nFrank H. Laukien, PhD, Bruker\u2019s President and CEO, said:<\/b> \u201cProteoforms are the fundamental unit of molecular disease. A single gene encodes one protein group but can give rise to over 50 protein variants through genetic variation, alternative splicing, post-translational modifications and protein processing. From just 20,000 human genes, these biological processes generate more than one million distinct functional \u2013 and sometimes pathological \u2013 human proteoforms.\u201d<\/i><\/p>

    \nHe continued: \u201cThe revolutionary timsOmni combines trapped ion mobility and trapped ExD technologies to give scientists higher dimensionality, unmatched top-down sensitivity and information-rich structural information for deeper insights. The unique OmniScape AI-driven top-down software transforms this biological complexity into clarity and insights. Deep functional proteoform analysis can now compress the path from discovery to biomarkers, precision medicine and novel therapies<\/i>. We have entered the era of deep, differentiated proteoform structural variant analysis for functional<\/b> proteomics 2.0 at scale, with profound benefits for a much deeper understanding of the molecular drivers of disease. This opens an unprecedented opportunity to accelerate drug discovery with meaningfully higher drug candidate success rates in humans.\u201d<\/i><\/p>

    \nA: Introducing the novel timsMRMS<\/b><\/p>

    \nThe timsMRMS redefines extreme-resolution mass spectrometry of complex mixtures, delivering mass resolving power of 1M to 10M, down to ppb mass accuracy, and a four orders of magnitude single-acquisition dynamic range through a fundamental breakthrough of TIMS gas-phase separation from MRMS detection. The unique timsMRMS delivers unrivaled performance for diverse applications, from molecular-level characterization in petroleomics to dissolved organic matter to biofuel fingerprinting and battery research in the energy industry.<\/p>

    \nB. Major strides in 4D bottom-up proteomics performance with timsUltra AIP<\/b><\/p>

    \nFurther instruments improvements, razor-PASEF methods and Spectronaut 21 software now further enhance deep proteome coverage at high throughput on the timsUltra AIP, enabling ID and quantification of >10,000 proteins in HeLa, and >6,500 proteins at 500 SPD.<\/p>

    \nA translational oncology initiative by Prof. Stephan Singer at University Hospital T\u00fcbingen, and Prof. Oliver Schilling at University of Freiburg, focused on FFPE tissue biopsy samples to elucidate actionable tumor biology, uncovering pathways that are invisible at the DNA\/RNA level.<\/p>

    \nStephan Singer commented: \u201cIn complex cancer cases, genomics does not always provide decision\u2011relevant answers, particularly with FFPE tissue. With timsTOF-based proteomics we routinely quantify more than 10,000 proteins across clinical samples, adding functional pathway activity, metabolic dependencies, and tumor\u2011specific resistance programs. This can enable proteomics\u2011driven therapy strategies exploiting signaling vulnerabilities and metabolic reprogramming, or new target discovery, where NGS remained inconclusive.\u201d<\/i><\/p>

    \nC:<\/b> New Argon option for timsOmni<\/b><\/p>

    \nFurther enhancing CID sensitivity by 4x for biomolecules, Argon offers advantages as a collision gas. As a heavy, mono-atomic noble gas with no internal vibrational or rotational modes, it transfers collision energy efficiently to precursor ions to drive efficient, reproducible dissociation.<\/p>

    \nD:<\/b> New Partnership with Integrated Protein Technologies<\/b><\/p>

    \nIntegrated Protein Technologies now interfaces their SampleStream directly with timsOmni under HyStar control, delivering automated, high-throughput buffer exchange via a molecular weight cutoff membrane that concentrates protein in a microfluidic flow cell while flushing buffers, salts, and adduct-forming excipients to waste, achieving MS-ready sample elution in under two minutes per sample with no carryover.<\/p>

    \nDr. Phil Compton, CEO, IPT said: \u201cWe\u2019ve always believed the future of proteomics depends on making high-performance intact and top-down workflows accessible. Combining SampleStream with timsOmni is a major step, and this technology can now reach scientists worldwide.<\/i>\u201d<\/p>

    \nE: AI-Software Innovations: OMNISCAPE, PROTEOSCAPE and GLYCOSCAPE 2027<\/b><\/p>

    \nBruker\u2019s software makes a leap forward with releases of OmniScape 2027, ProteoScape 2027, and GlycoScape 2027, for confidence in top-down proteoform sequence and PTM analysis.<\/p>

    \nA novel addition to Omniscape 2027 is LYRA<\/b>, a de novo<\/i><\/b> algorithm that transforms high-quality sequence reads from complex top-down spectra into annotated protein sequences. LYRA features ultrafast PTM screening for proteoform ID across billions of possibilities and an advanced result combination module for higher sequence coverage and safer proteoform and PTM assessment.<\/p>

    \nNew automated glycoproteomics workflows incorporate both trapped electron capture dissociation (tECD) with low-energy electrons and complementary trapped electron ionization dissociation (tEID) using higher-energy electrons, for dissociation reaction times as short as 10 ms.<\/p>

    \nAll glycoproteomics workflows are now compatible with MSFragger. Professor Alexey Nesvizhskii, University of Michigan, said: \u201cMSFragger\u2019s support for timsOmni trapped EXD acquisitions brings peptide-backbone sequencing and glycan-informative fragmentation into a single framework for bottom-up glycoproteomics. This enables more confident site localization while improving the ability to resolve glycan composition and structural features directly from routine LC\u2013MS\/MS data.\u201d<\/i><\/p>

    \ntims-Casanovo, a collaboration with Professor William Nobel at University of Washington, Professor Fabian Theis at Helmholtz Munich, and Professor Wout Bittremieux at University of Antwerp, and the Bruker software team, uses a transformer neural network to translate peaks in MS\/MS spectra into amino acid sequences with exceptional precision.<\/p>

    \nBill Noble stated: \u201ctims-Casanovo expands the training datasets significantly, improving precision, enabling robust peptide detection across challenging applications, including immunopeptidomics, antibody characterization, and analyses with incomplete reference databases.\u201d<\/i><\/p>

    \nF: Advancements in 4D Metabolomics and Air Exposomics<\/b><\/p>

    \nMetaboScape\u00ae now supports ecTOF\u2122 dual ionization, enabling processing of simultaneous EI and CI spectra for GC-HRAM chemical exposure coverage. Bruker launches an early-access program for hybrid metabolomics on timsMetabo\u2122, combining kit-based absolute quantitation with discovery in a \u2018holy grail\u2019 qual\/quant simultaneous targeted and discovery experiment.<\/p>

    \nDr. Michael Witting, Helmholtz Munich, said: <\/b>\"Metabolomics research demands both quantitative data and broad exploratory coverage, but combining these has meant separate workflows, adding complexity. Bringing targeted and untargeted metabolomics together in a single experiment simplifies large-scale studies for a more complete picture of metabolic changes driving disease.\"<\/i><\/p>

    \nFollowing its acquisition of TOFWERK in January 2026, Bruker is launching an Air Exposomics initiative that combines TOFWERK Vocus\u2122 real-time VOC monitoring and mipTOF\u2122 field-deployable trace-metal aerosol analyzer with 4D metabolomics and lipidomics. This portfolio can connect real-time environmental exposure measurements to respiratory illness, neurodegeneration, and cancer. Professor Peter DeCarlo, Department of Environmental Health and Engineering, Johns Hopkins University, said: \u201cThis is a pivotal moment for air exposomics, combining real-time air monitoring with multiomics capabilities to advance our understanding of how air pollutant exposures are expressed in human biological systems.\u201d<\/p>

    \nAbout Bruker Corporation \u2013 Leader of the Post-Genomic Era <\/b>(Nasdaq: BRKR)<\/p>

    \nBruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker\u2019s high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy, as well as in industrial and cleantech research, and semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, proteomics and multiomics, spatial and single-cell biology, structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. For more information, please visit www.bruker.com<\/a>.<\/p> Contacts<\/b>

    \nInvestor Contact:\nJoe Kostka<\/b>Director, Investor Relations\nBruker Corporation\nT: +1 (978) 313-5800\nE: Investor.Relations@bruker.com<\/a>\nMedia Contact:<\/b>Nora Williams\nVP, Global Marketing and Communications\nBruker Daltonics\nT: +44 2476855225\nE: pr@bruker.com<\/a><\/p>","protected":false},"excerpt":{"rendered":"

    Bruker Also Launches Two Novel Mass Spectrometry Systems for Unique Applications in Energy Industry Research, and in Semiconductor Manufacturing<\/p>\n

    Launch of eXtreme 10M resolution novel timsMRMS\u2122 mass spectrometer for ultra-complex mixture analysis in …<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-13790","post","type-post","status-publish","format-standard","hentry","category-infos-businesswire"],"_links":{"self":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts\/13790","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=13790"}],"version-history":[{"count":1,"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts\/13790\/revisions"}],"predecessor-version":[{"id":13791,"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts\/13790\/revisions\/13791"}],"wp:attachment":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=13790"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=13790"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=13790"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}