{"id":24029,"date":"2026-06-22T16:00:00","date_gmt":"2026-06-22T14:00:00","guid":{"rendered":"http:\/\/stocks-future.com\/?guid=1477be6ffcdd6d7c4854c8a3ff443a0f"},"modified":"2026-06-22T16:00:00","modified_gmt":"2026-06-22T14:00:00","slug":"bionyra-pharma-launches-with-165-million-oversubscribed-series-a-to-advance-clinical-stage-pipeline-of-next-generation-biologics-for-immune-mediated-inflammatory-diseases","status":"publish","type":"post","link":"https:\/\/stocks-future.com\/?p=24029","title":{"rendered":"Bionyra Pharma Launches with $165 million Oversubscribed Series A to Advance Clinical Stage Pipeline of Next Generation Biologics for Immune-Mediated Inflammatory Diseases"},"content":{"rendered":"<ul class=\"bwlistdisc\">\n<li>\n<i>Series A co-led by Jeito Capital and Sofinnova Partners, with participation from Arkin Bio, Sanofi Ventures, Sixty Degree Capital, Vives Partners and Apollo Health Ventures<\/i><\/li>\n<\/ul><ul class=\"bwlistdisc\">\n<li>\n<i>Sofinnova Partners seed financed and co-founded Bionyra alongside Fr\u00e9d\u00e9ric Marrache, MD, PhD, CEO of the company<\/i><\/li>\n<\/ul><ul class=\"bwlistdisc\">\n<li>\n<i>Pipeline includes clinical and IND stage<\/i> <i>mono and multispecific antibodies with half-life extension engineering across immune-mediated inflammatory diseases<\/i><\/li>\n<\/ul><p>PARIS & BOSTON--(BUSINESS WIRE)--<a href=\"https:\/\/twitter.com\/hashtag\/Atopicdermatitis?src=hash\" >#Atopicdermatitis<\/a>--Bionyra Pharma, a clinical-stage biopharmaceutical company developing next-generation biologics for immune-mediated inflammatory diseases, today announced the company\u2019s launch and its $165 million (~\u20ac143 million) oversubscribed Series A financing co-led by Jeito Capital and Sofinnova Partners. Arkin Bio, Sanofi Ventures, Sixty Degree Capital, Vives Partners and Apollo Health Ventures also participated in this inaugural funding. The company received seed financing from Sofinnova Partners and was co-founded with former Sanofi R&amp;D executive Dr. Fr\u00e9d\u00e9ric Marrache, who serves as CEO of the company. Bionyra is advancing next-generation mono and multispecific antibodies for diseases with high unmet need despite currently available treatments, including atopic dermatitis and inflammatory bowel disease (IBD).<\/p><br\/><a href=\"https:\/\/mms.businesswire.com\/media\/20260622319137\/en\/2835906\/5\/Bionyra_Logo.jpg\"><img src=\"https:\/\/mms.businesswire.com\/media\/20260622319137\/en\/2835906\/22\/Bionyra_Logo.jpg\" \/><\/a><br\/><a href=\"https:\/\/mms.businesswire.com\/media\/20260622319137\/en\/2835906\/5\/Bionyra_Logo.jpg\"><img src=\"https:\/\/mms.businesswire.com\/media\/20260622319137\/en\/2835906\/21\/Bionyra_Logo.jpg\" \/><\/a><p>\n\u201cMore than half of patients suffering from immune-mediated inflammatory diseases remain inadequately controlled, highlighting a significant need for better treatment options. Across our pipeline, we are selectively modulating immune pathways that are central drivers of disease in indications where current therapies remain insufficient,\u201d said Dr. Marrache, Co-founder and CEO of Bionyra. \u201cWe have built Bionyra around assets and targets with clear therapeutic rationale, relevant biology and optimized clinical strategy to develop therapies that will deliver meaningful impact to people who don\u2019t currently have good options.\u201d<\/p><p>\nSevere immunological and inflammatory diseases impose a constant toll, as patients live with a high daily burden of pain, fatigue and uncertainty, structuring their lives around flares, hospital visits and treatment setbacks. Current therapies often target single nodes of complex immune networks, limiting depth and durability of response. Many patients cycle through multiple therapies without achieving sustained relief or meaningful improvements in quality of life, highlighting the need for better therapeutic options that can improve clinical outcomes.<\/p><p>\nBionyra is launching with a broad pipeline of clinical and near-clinical, next-generation anti-inflammatory therapies designed to deliver first- and best-in-class treatments by combining multi-pronged biology with optimized pharmacokinetics to maximize efficacy and patient benefit, including:<\/p><ul class=\"bwlistdisc\">\n<li>\n<b>BYN-002 <\/b>\u2014 a leading TL1A monoclonal antibody with half-life extension (HLE) technology with best-in-class potential in IBD and other TL1A-relevant indications. A Phase 1 study in healthy subjects is fully enrolled.<\/li>\n<\/ul><ul class=\"bwlistdisc\">\n<li>\n<b>BYN-003 <\/b>\u2014 a first and best-in-class TL1A*IL-23p19 bispecific antibody with HLE technology that entered the clinic in April with a Phase 1 study now underway.<\/li>\n<\/ul><ul class=\"bwlistdisc\">\n<li>\n<b>BYN-001 <\/b>\u2014 a first and best-in-class IL-25 monoclonal antibody with HLE technology in IND-stage for atopic dermatitis and Type 2 inflammation.<\/li>\n<\/ul><p>\nThe company licensed BYN-002 and BYN-003 from TrueLab Biopharmaceutical<sup>1<\/sup> and BYN-001 from NovaRock Biotherapeutics<sup>2<\/sup> and holds exclusive global rights outside of Greater China. In addition, Bionyra is progressing additional innovative preclinical assets, including some from TrueLab.<\/p><p>\n\u201cSo many patients suffering from immune-mediated inflammatory diseases still face daily burden due to limited treatment options,\u201d said Mehdi Ainouche, Partner at Jeito Capital. \u201cBionyra is uniquely positioned to accelerate delivery of highly promising therapies to patients through a focused and well-designed clinical development strategy aimed at rapidly generating clinical validation and addressing key unmet needs like deeper remission and alternatives for non-responders. We look forward to supporting Fr\u00e9d\u00e9ric and the entire Bionyra team as the company reaches a pivotal stage in its development while simultaneously building a scalable pipeline in dermatology and IBD.\u201d<\/p><p>\n\u201cWhen we co-founded Bionyra with Fr\u00e9d\u00e9ric, our conviction in both the company and his leadership was grounded in his deep expertise in immune and inflammatory diseases. Today, that conviction is reflected in a $165 million oversubscribed round backed by an exceptional syndicate of investors who share our belief in this pipeline and the team behind it. Looking ahead, we are focused on advancing these programs with the aim of bringing meaningful new treatment options to patients,\u201d said Anta Gkelou, Partner at Sofinnova Partners.<\/p><p>\nBionyra\u2019s world-class team is led by Fr\u00e9d\u00e9ric Marrache, MD, PhD, a former senior pharmaceutical executive with extensive experience in immunology and inflammation. Prior to joining Bionyra as CEO, Fr\u00e9d\u00e9ric served as Vice President and Executive Global Project Head for Clinical Development in the Immunology and Inflammation Therapeutic Area at Sanofi, where he led a portfolio of early- to mid-stage drug development programs focused on immune-mediated diseases. Fr\u00e9d\u00e9ric holds an MD in gastroenterology, a PhD, and an MBA.<\/p><p>\nMehdi Ainouche, Partner at Jeito Capital; Anta Gkelou, Partner at Sofinnova Partners; Avital Adler, Principal at Arkin Bio; and Laia Crespo, Partner at Sanofi Ventures, will join Bionyra\u2019s Board of Directors.<\/p><p>\n<b>About Bionyra Pharma<\/b><\/p><p>\nBionyra Pharma is a clinical-stage biopharmaceutical company developing next-generation biologics for severe immunological and inflammatory diseases. Bionyra\u2019s best-in-class mono and multispecific antibodies with half-life extension technology target novel immune pathways, enabling deeper and more durable disease control, with an initial focus on atopic dermatitis and inflammatory bowel disease. Seed financed by Sofinnova Partners, Bionyra was co-founded by Sofinnova Partners and Fr\u00e9d\u00e9ric Marrache, MD, PhD, MBA, a former Sanofi R&amp;D executive with deep immunology expertise. The company is committed to overcoming the limitations of existing therapies by delivering patient-optimized treatments with greater efficacy and improved convenience, offering better and longer-lasting outcomes. For more information, visit <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fbionyra.com%2F&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=Bionyra.com&amp;index=1&amp;md5=f1b21999d667ee63b3ff121cdf7653da\" rel=\"nofollow\" shape=\"rect\">Bionyra.com<\/a> and follow us on <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fbionyra%2Fabout%2F&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=2&amp;md5=2dca127cc0b14dfaf36a428b64d2a7cf\" rel=\"nofollow\" shape=\"rect\">LinkedIn<\/a>.<\/p><p>\n<b>About Sofinnova Partners<\/b><\/p><p>\nSofinnova Partners is a leading European venture capital firm in life sciences, specializing in healthcare and sustainability. Based in Paris, London and Milan, the firm brings together a team of professionals from all over the world with strong scientific, medical and business expertise. Sofinnova Partners is a hands-on company builder across the entire value chain of life sciences investments, from seed to later-stage.<\/p><p>\nFounded in 1972, Sofinnova Partners is a deeply established venture capital firm in Europe, with 50 years of experience backing over 500 companies and creating market leaders around the globe. Today, Sofinnova Partners manages over \u20ac4 billion in assets. For more information, please visit: <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sofinnovapartners.com%2F&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=sofinnovapartners.com&amp;index=3&amp;md5=4df33a284cd0a35e47927d8c62b7bdc1\" rel=\"nofollow\" shape=\"rect\">sofinnovapartners.com<\/a>.<\/p><p>\n<b>About Jeito Capital<\/b><\/p><p>\nJeito Capital is a global leading private equity firm with a patient benefit driven approach that finances and accelerates the development and growth of ground-breaking medical innovation. With \u20ac1.6 billion in assets under management, Jeito empowers and supports managers through its expert, integrated, multi-talented team and through the investment of significant capital to ensure the growth of companies, building market leaders in their respective therapeutic areas with accelerated patients\u2019 access globally, especially in Europe and the United States. Jeito has built a diversified portfolio of clinical biopharmas with cutting-edge innovations addressing high unmet needs. Jeito Capital is based in Paris with a presence in Europe and the United States.<\/p><p>\nFor more information, please visit <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.jeito.life&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=www.jeito.life&amp;index=4&amp;md5=ab0093d3fa8da90ec7d769bafdb972b3\" rel=\"nofollow\" shape=\"rect\">www.jeito.life<\/a> or follow us on <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Fwww.linkedin.com%2Fcompany%2Fjeito-life%2F&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=LinkedIn&amp;index=5&amp;md5=f6951d22f53ecb8292c7d2557d0df08e\" rel=\"nofollow\" shape=\"rect\">LinkedIn<\/a>.<\/p><p>\n<b>About Arkin Bio Capital<\/b><\/p><p>\nArkin Bio Capital is a global biotech fund dedicated to supporting clinical stage biotech companies approaching proof of concept in patients. Arkin Bio Capital leads investments alongside top global partners, driving robust growth and impactful advancements. Arkin\u2019s team has a strong background in biopharmaceuticals, drug development, business development, and management, with a proven track record. Arkin Bio Capital seeks to invest in companies with innovative therapeutic candidates and experienced managements and is committed to nurturing promising opportunities and ensuring the success of each investment. For more information about Arkin Bio Capital, please visit <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=https%3A%2F%2Farkin-capital.com%2Fbio%2F&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=https%3A%2F%2Farkin-capital.com%2Fbio%2F&amp;index=6&amp;md5=910f8ed08e9cf2f91850526ed8386754\" rel=\"nofollow\" shape=\"rect\">https:\/\/arkin-capital.com\/bio\/<\/a>.<\/p><p>\n<b>About Sanofi Ventures<\/b><\/p><p>\nSanofi Ventures is the corporate venture capital arm of Sanofi, focused on investing in promising early-stage healthcare companies. The firm supports pioneering innovations in biotechnology, digital health, and life sciences aligning with Sanofi\u2019s mission to bring life-changing treatments to patients worldwide. For more information, please visit <a  href=\"https:\/\/cts.businesswire.com\/ct\/CT?id=smartlink&amp;url=http%3A%2F%2Fwww.sanofiventures.com&amp;esheet=54557567&amp;newsitemid=20260622319137&amp;lan=en-US&amp;anchor=www.sanofiventures.com&amp;index=7&amp;md5=1816a584fb4cf52f0d75449b9df63827\" rel=\"nofollow\" shape=\"rect\">www.sanofiventures.com<\/a>.<\/p><table cellspacing=\"0\" class=\"bwtablemarginb bwblockalignl\">\n<tr>\n<td class=\"bwpadl0\" colspan=\"3\" rowspan=\"1\">__________________________<\/td>\n<\/tr>\n<tr>\n<td class=\"bwpadl0 bwpadr0 bwpadb3 bwalignl bwvertalignt\" colspan=\"1\" rowspan=\"1\"><p class=\"bwcellpmargin bwalignl\">\n<sup>1<\/sup><\/p><\/td><td colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwvertalignt bwpadl0\" colspan=\"1\" rowspan=\"1\"><p class=\"bwcellpmargin\">\nBYN-002 is also known as TL-001 and BYN-003 as TL-003.<\/p><\/td><\/tr>\n<tr>\n<td class=\"bwpadl0 bwpadr0 bwpadb3 bwalignl bwvertalignt\" colspan=\"1\" rowspan=\"1\"><p class=\"bwcellpmargin bwalignl\">\n<sup>2<\/sup><\/p><\/td><td colspan=\"1\" rowspan=\"1\">\u00a0<\/td>\n<td class=\"bwvertalignt bwpadl0\" colspan=\"1\" rowspan=\"1\"><p class=\"bwcellpmargin\">\nBYN-001 is also known as NBL-023.<\/p><\/td><\/tr>\n<\/table><p>\n\u00a0<\/p><br\/> <b>Contacts<\/b> <br\/><p>\n<b>Media<\/b><br\/>Michelle Linn\n<br\/>Linnden Communications\n<br\/><a  href=\"mailto:michelle@linndencom.com\" rel=\"nofollow\" shape=\"rect\">michelle@linndencom.com<\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>Series A co-led by Jeito Capital and Sofinnova Partners, with participation from Arkin Bio, Sanofi Ventures, Sixty Degree Capital, Vives Partners and Apollo Health Ventures<\/p>\n<p>Sofinnova Partners seed financed and co-founded Bionyra alongside Fr\u00e9d\u00e9ric &#8230;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-24029","post","type-post","status-publish","format-standard","hentry","category-infos-businesswire"],"_links":{"self":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts\/24029","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=24029"}],"version-history":[{"count":1,"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts\/24029\/revisions"}],"predecessor-version":[{"id":24030,"href":"https:\/\/stocks-future.com\/index.php?rest_route=\/wp\/v2\/posts\/24029\/revisions\/24030"}],"wp:attachment":[{"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=24029"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=24029"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/stocks-future.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=24029"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}